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    中国科学院化学研究所,中关村北一街2号,100190,北京
电话:(010) 82362540;电邮:wangzh[at]iccas.ac.cn
 
 
         研究方向  
      2017年7月进入中科院化学所工作,主要从事多肽功能化纳米材料的制备及其生物医学应用研究  
 
         个人简历  
      1985年5月                出生于甘肃省庄浪县  
      2001-2004                甘肃省庄浪县第二中学(高中)  
      2004-2008                甘肃陇东学院生命科学系(本科)  
      2008.07-2012.02       石河子大学农业生物技术重点实验室,硕士  
      2012.04-2012.10       中国农业科学院植物保护研究所,科研助理  
      2012.10-2014.09       国家纳米科学中心,科研助理  
      2014.09-2017.07       国家纳米科学中心(博士)  
      2017.07-至今            中国科学院化学研究所,助理研究员  
 
         发表论文  
   
  1. Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip
    Ren Li, Mingxing Zhou, Jine Li, Zihua Wang, Weikai Zhang, Chunyan Yue, Yan Ma, Hailin Peng, Zewen Wei, Zhiyuan Hu*
    Nano-Micro Lett. 2018, DOI:10.1007/s40820-017-0168-y.
  2. Precisely Enumerating Circulating Tumor Cells Utilizing a Multi-Functional Microfluidic Chip and Unique Image Interpretation Algorithm
    Mingxing Zhou, Hui Zheng, Zhaoba Wang, Ren Li, Xiaoran Liu, Weikai Zhang, Zihua Wang,
    Huiping Li, Zewen Wei, Zhiyuan Hu*
    Theranostics 2017, 7(19): 4710-4721.
  3. Peptide probes Derived from Pertuzumab by Molecular dynamics Modeling for HER2 Positive Tumor Imaging
    Xiaoliang Yang, Zihua Wang, Zhichu Xiang, Dan Li, Zhiyuan Hu,Wei Cui, Lingling Geng, Qiaojun Fang*
    PLoS Comput. Biol. 2017, 13(4): e1005441.
  4. Tumor detection using Magnetosome Nanoparticles Functionalized with a newly Screened EGFR/HER2 Targeting Peptide
    Zhichu Xiang, Xiaoliang Yang, Junjie Xu, Wenjia Lai, Zihua Wang, Zhiyuan Hu*, Jiesheng Tian, Lingling Geng, Qiaojun Fang*
    Biomaterials 2017, 115, 53-64.
  5. PECT/CT Imaging of the Novel HER2-targeted Peptide Probe 99mTc-HYNIC-H6F in Breast Cancer Mouse Models
    Liqiang Li, Yue Wu, Zihua Wang, Bing Jia, Zhiyuan Hu, Chengyan Dong, and Fan Wang*
    J. Nucl. Med. 2017, 58(5):821-826.
  6. Targeting Peptide Functionalized Liposomes towards Aminopeptidase N for Precise Tumor Diagnosis and Therapy
    Xiangqian Jia, Qiuju Han, Zihua Wang, Yixia Qian, Yunhong Jia, Weizhi Wang, Zhiyuan Hu*
    Biomater. Sci. 2017, 5, 417-421.
  7. Switchable Liposomes: Targeting Peptides Functionalized and pH-Triggered Cytoplasmic Delivery
    Qiuju Han, Weizhi Wang, Xiangqian Jia, Yixia Qian, Qian Li, Zihua Wang, Weikai Zhang, Shu Yang, Yunhong Jia, Zhiyuan Hu*
    ACS Appl. Mater. Interfaces 2016, 8, (29), 18658-18663.
  8. Micromixer based Preparation of Functionalized Liposomes and Targeting Drug Delivery
    Xiangqian Jia, Weizhi Wang, Qiuju Han, Zihua Wang, Yunhong Jia, Zhiyuan Hu*
    ACS Med. Chem. Lett. 2016, 7, 429-434.
  9. Switchable Probes: pH-Triggered and VEGFR2 Targeted Peptides Screening through Imprinting Microarray
    Yixia Qian, Weizhi Wang, Zihua Wang, Qiuju Han, Xiangqian Jia, Shu Yanga, Zhiyuan Hu*
    Chem. Commun. 2016, 52, 5690-5693.
  10. Peptide Functionalized Targeting Liposomes: for Nanoscale Drug Delivery towards Angiogenesis
    Qiuju Han, Xiangqian Jia, Yixia Qian, Zihua Wang, Shu Yang, Yunhong Jia,Weizhi Wang, Zhiyuan Hu*
    J. Mater. Chem. B, 2016, 4, 7087-7091
  11. Peptide-Conjugated PEGylated PAMAM as a High Affinitive Nanocarrier towards HER2-overexpressing Cancer Cells
    Iman Rostami, Zijian Zhao, Zihua Wang, Weikai Zhang, Yeteng Zhong, Qiang Zeng, Xinru Jia*, Zhiyuan Hu*
    RSC Adv. 2016, 6, 107337-107343
  12. HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery Lingling Geng, Zihua Wang, Xiangqian Jia, Qiuju Han, Zhichu Xiang, Dan Li, Xiaoliang Yang, Di Zhang, Xiangli Bu, Weizhi Wang, Zhiyuan Hu*, Qiaojun Fang*
    Theranostics 2016, 6(8), 1261-1273
  13. Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor
    Zihua Wang, Weizhi Wang, Xiangli Bu, Zewen Wei, Lingling Geng, Yue Wu, Chengyan Dong,
    Liqiang Li, Di Zhang, Shu Yang, Fan Wang, Christopher Lausted, Leroy Hood, Zhiyuan Hu*
    Anal. Chem. 2015, 87, 8367-8372
  14. Distinguishing of Tumor Cell-targeting Peptide ligands through a Color-encoding Microarray
    Zihua Wang, Weizhi Wang, Lingling Geng, Zhiyuan Hu*
    Lab Chip 2015, 15, 4512-4516
  15. Discovering of Tumor-targeting Peptides using Bi-functional Microarray
    Weizhi Wang, Zihua Wang, Xiangli Bu, Ren Li, Mingxing Zhou, Zhiyuan Hu*
    Adv. Healthc. Mater. 2015, 4, 2802-2808
  16. Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors
    Lingling Geng, Zihua Wang, Xiaoliang Yang, Dan Li, Wenxi Lian, Zhichu Xiang, Weizhi Wang, Xiangli Bu,Wenjia Lai, Zhiyuan Hu*, Qiaojun Fang*
    Theranostics 2015, 5(10), 1154-1165
  17. Energy Migration Engineering of Bright Rare-Earth Upconversion Nanoparticles for Excitation by Light Emitting Diodes
    Yeteng Zhong, Iman Rostami, Zihua Wang, Hongjie Dai*, Zhiyuan Hu*
    Adv. Mater., 2015, 27, 6418-6422
  18. Label-free detection Microarray for novel Peptide ligands Screening base on MS-SPRi combination
    Weizhi Wang, Di Zhang, Zewen Wei, Zihua Wang, Xiangli Bu, Shu Yang, Qiaojun Fang, Zhiyuan Hu*
    Talanta 2015, (134) 705-711
  19. A Continuous Flow Micro?uidic-MS system for e?cient OBOC Screening
    Weizhi Wang, Zewen Wei, Zihua Wang, Huailei Ma, Xiangli Bu, Zhiyuan Hu*
    RSC Adv. 2014, 4, 61767-61770
  20. Bimodal Imprint Chips for Peptide Screening: Integration of High-Throughput Sequencing by MS and A?nity Analyses by Surface Plasmon Resonance Imaging
    Weizhi Wang, Menglin Li, Zewen Wei, Zihua Wang, Xiangli Bu, Wenjia Lai, Shu Yang, He Gong, Hui Zheng, Yuqiao Wang, Ying Liu, Qin Li, Qiaojun Fang, Zhiyuan Hu*
    Anal. Chem. 2014, 86, 3703-3707
  21. Rapid Screening of Peptide Probes through In Situ Single-Bead Sequencing Microarray
    Weizhi Wang, Zewen Wei, Di Zhang, Huailei Ma, Zihua Wang, Xiangli Bu, Menglin Li, Lingling Geng, Christopher Lausted, Leroy Hood, Qiaojun Fang, Hao Wang, Zhiyuan Hu*
    Anal. Chem. 2014, 86, 11854-11859
  22. An automated Teflon Microfluidic Peptide Synthesizer
    Hui Zheng, Weizhi Wang, Xiaojun Li, Zihua Wang, Leroy Hood, Christopher Lausted, Zhiyuan Hu*
    Lab Chip 2013, 13, 3347-3350
 
         申请专利  
   
  1. 一种靶向人乳腺癌细胞的多肽及其应用
    王子华,王蔚芝,胡志远
    中国发明专利申请(201410453048.8)
    申请日期:2014年9月5日
    授权日期:2017年6月23日
  2. 一种靶向人癌细胞的多肽及其应用 王蔚芝,王子华,胡志远
    中国发明专利申请(201410437046.X)
    申请日期:2014年8月29日
    授权日期:2016年10月5日
  3. 一种稀土上转换纳米颗粒及其制备方法和用途
    胡志远,钟业腾,王子华
    中国发明专利申请(201510551274.4) 
    申请日期:2015年9月1日
    授权日期:2017年12月8日
  4. 一种肿瘤靶向多肽及其制备方法和应用
    胡志远,王子华,王蔚芝,钱怡霞
    中国发明专利申请(201510658825.7)
    申请日期:2015年10月12日
  5. 一种pH响应且靶向人肿瘤血管标记物VEGFR2的多肽及其应用
    钱怡霞,王蔚芝,王子华,胡志远
    中国发明专利申请(201510753390.4)
    申请日期:2015年11月6日
  6. 一种靶向HER2的新型多肽放射性制剂及制备方法和用途
    王凡,董诚岩,胡志远,史继云,贾兵,王子华,李立强,吴越,刘昭飞,赵慧云
    中国发明专利申请(201611095338.5)
    申请日期:2016年12月2日
  7. 一种靶向纳米药物载体及其制备方法和应用
    伊曼,王子华,胡志远
    中国发明专利申请(201710245436.0)
    申请日期:2017年4月14日
  8. 一种靶向肿瘤干细胞标志物CD133的多肽及其应用
    王子华,王蔚芝,胡志远
    中国发明专利申请(201710471867.9) 
    申请日期:2017年6月20日
  9. 一种肿瘤免疫治疗预测生物标志物PD-L2靶向多肽及其应用
    王子华,胡志远
    中国发明专利申请(201710571410.5)
    申请日期:2017年7月13日
 
 
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