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    乔瑞瑞  
 
    中国科学院化学研究所，中关村北一街2号，100190，北京
电话：(010) 82613214，62625212，传真：(010) 82613214
电邮：qiaorr[at]iccas.ac.cn		  
 
         研究方向  
      2007年7月进入中科院化学所工作，研究方向主要为磁性纳米晶体的合成、表征与生物应用。  
 
         个人简历  
      1983年9月               出生于山西  
      1998-2001               山西临汾第一中学（高中）  
      2001.9-2007.7     北京大学药学院药学专业（本硕连读）  
      2007.07-2009.10     化学所助理研究员  
      2009.10-2010.01     德国明斯特大学，访问交流  
      2012.01-2012.03     德国明斯特大学，访问交流  
      2011-2014              化学所在职博士生  
      2014年5月20日       通过博士论文答辩  
      2016.03-至今          中国科学院化学研究所，副研究员  
 
         发表论文  
   
  1. MRI/Optical Dual-modality Imaging of Vulnerable Atherosclerotic Plaque with an Osteopontin-targeted Probe based on Fe3O4 Nanoparticles
    Hongyu Qiao‡, Ruohan Zhang‡, Yabin Wang‡, Xiao Liang, Lei Gao, Zhenhua Jiang, Ruirui Qiao, Dong Han, Yan Zhang, Bin Xu, Jie Tian, Mingyuan Gao*, Feng Cao*
    Biomaterials, 2017, 112, 336–345.
  2. Detection of Early Primary Colorectal Cancer with Upconversion Luminescence NPs‐Based Molecular Probes
    Chunyan Liu‡, Yifei Qi‡, Ruirui Qiao, Yi hou, Kaying Chan, Ziqian Li, Jiayi Huang, Lihong Jing, Jun Du*, and Mingyuan Gao*
    Nanoscale, 2016, 8(48), 12579-12587.
  3. Imaging Tumor Metastases with Molecular Probes
    Ruirui Qiao, Ran Zhu, and Mingyuan Gao*
    Curr. Pharm. Design, 2015, 21(42), 6260-6264.
  4. Aqueous Synthesis of PEGylated Copper Sulfide Nanoparticles for Photoacoustic Imaging of Tumors
    Ke Ding, Jianfeng Zeng, Lihong Jing, Ruirui Qiao*, Chunyan Liu, Mingxia Jiao, Zhen Li, and Mingyuan Gao*
    Nanoscale, 2015, 7(25), 11075-11081.
  5. Ultrasensitive in Vivo Detection of Primary Gastric Tumor and Lymphatic Metastasis Using Upconversion Nanoparticles
    Ruirui Qiao, Changhao Liu, Muhan Liu, Hao Hu, Chunyan Liu, Yi Hou, Kaichun Wu*, Yenan Lin, Jimin Liang, Mingyuan Gao*
    ACS Nano, 2015, 9(2), 2120–2129.
  6. In vivo Multimodality Imaging of miRNA-16 Iron Nanoparticle Reversing Drug Resistant to Chemotherapy in A Mouse Gastric Cancer Model
    Zhongchan Sun, Xinxing Song, Xiujuan Li, Shun Qi, Ruirui Qiao, Tao Su, Fu Wang, Weidong Yang, Yi Huan, Jing Wang, Yongzhan Nie, Kaichun Wu, Mingyuan Gao and Feng Cao*
    Nanoscale, 2014, 6(23), 14343-14353.
  7. Strategies to overcome the barrier: use of nanoparticles as carriers and modulators of barrier properties
    Ralf Rempe, Sandra Cramer, Ruirui Qiao, Hans-Joachim Galla*
    Cell Tissue Res., 2014, 355(3), 717.
  8. Anchoring Group Effects of Surface Ligand on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents
    Jianfeng Zeng, Lihong Jing, Yi Hou, Mingxia Jiao, Ruirui Qiao, Qiaojuan Jia, Chunyan Liu, Fang Fang, Hao Lei, and Mingyuan Gao*
    Adv. Mater., 2014, 26(17), 2694-2698.
  9. In Situ 111In-doping for Achieving Biocompatible and Non-leachable 111In-labeled Fe3O4 Nanoparticles
    Jianfeng Zeng, Bing Jia, Ruirui Qiao, Chao Wang, Lihong Jing, Fan Wang and Mingyuan Gao*
    Chem. Commun., 2014, 50(17), 2170-2172.
  10. Aqueous Manganese-Doped Core/Shell CdTe/ZnS Quantum Dots with Strong Fluorescence and High Relaxivity
    Lihong Jing, Ke Ding, Sergii Kalytchuk, Yu Wang, Ruirui Qiao, Stephen Kershaw, Andrey L. Rogach,* and Mingyuan Gao*
    J Phys. Chem. C, 2013, 117(36), 18752-18761.
  11. Ultrasmall PEGylated MnxFe3-xO4 (x=0-0.34) nanoparticles: effects of Mn(II) doping on T-1-and T-2-weighted magnetic resonance imaging
    Lijing Wang, Qiong Wu, Su Tang, Jianfeng Zeng, Ruirui Qiao, Pan Zhao, Yuan Zhang, Fengqin Hu*, and Mingyuan Gao
    RSC Adv., 2013, 3(45), 23454-23460.
  12. Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo
    Chunyan Liu, Zhenyu Gao, Jianfeng Zeng, Yi Hou,* Fang Fang, Yilin Li, Ruirui Qiao, Lin Shen, Hao Lei, Wensheng Yang, and Mingyuan Gao*
    ACS Nano, 2013, 7(8), 7227-7240.
  13. NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts In Vivo
    Yi Hou, Ruirui Qiao, Fang Fang, Xuxia Wang, Chengyan Dong, Kan Liu, Chunyan Liu, Zhaofei Liu, Hao Lei*, Fan Wang, and Mingyuan Gao*
    ACS Nano, 2013, 7(1), 330-338.
  14. Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood-Brain Barrier
    Ruirui Qiao, Qiaojuan Jia, Sabine Hüwel, Rui Xia, Ting Liu, Fabao Gao*, Hans-Joachim Galla*, and Mingyuan Gao*
    ACS Nano, 2012, 6(4), 3304-3310.
  15. 磁性氧化铁纳米颗粒－通向肿瘤磁共振分子影像的重要基石
    乔瑞瑞，曾剑峰，贾巧娟，杜军，沈琳，高明远*
    物理化学学报，2012，28(5)，993-1011.（综述论文）
    Magnetic Iron Oxide Nanoparticle – an Important Corestone towards MR Molecular Imaging of Tumor
    Ruirui Qiao, Jianfeng Zeng, Qiaojuan Jia, Jun Du, Lin Shen, Mingyuan Gao*
    Acta Phys-Chim.Sin., 2012, 28(5), 993-1011. (Review article)
  16. 不同表面修饰的Fe3O4纳米颗粒在体肿瘤成像研究
    乔瑞瑞，刘侃，贾兵，曾剑峰，欧阳汉，王凡，高明远*
    东南大学学报（医学版）, 2011, 30(1), 63-66.
    In vivo MR Imaging of Tumor by using Fe3O4 Nanopartilces Bearing with Different Surface Ligand as Contrast Agent
    Ruirui Qiao, Kan Liu, Bing Jia, Jianfeng Zeng, Han Ouyang, Fan Wang, Mingyuan Gao*
    J. Southeast Univ. (Med. Sci. Edi.), 2011, 30(1), 63-66.
  17. Surface-biofunctionalized Multicore/Shell CdTe@SiO2 Composite Particles for Immunofluorescence Assay
    Lihong Jing, Yilin Li, Ke Ding, Ruirui Qiao, Andrey L. Rogach, Mingyuan Gao*
    Nanotechnology, 2011, 22(50), 505104.
  18. 磁性氧化铁纳米颗粒及其磁共振成像应用
    乔瑞瑞，贾巧娟，曾剑峰，高明远
    生物物理学报, 2011, 27(4), 272-288.
    Magnetic Iron Oxide Nanoparticles and Their Applications in Magnetic Resonance Imaging
    Ruirui Qiao, Qiaojuan Jia, Jianfeng Zeng, Mingyuan Gao*
    Acta Biophysica Sinica,2011, 27(4), 272-288.
  19. Gelification: An Effective Measure for Achieving Differently Sized Biocompatible Fe3O4 Nanocrystals through a Single Preparation Recipe
    Qiaojuan Jia, Jianfeng Zeng, Ruirui Qiao, Lihong Jing, Liang Peng, Fenglong Gu*, and Mingyuan Gao*
    J. Am. Chem. Soc., 2011, 133(48), 19512-19523.
  20. Aqueous Synthesis of CdTe Nanocrystals: Progresses and Perspectives
    Yilin Li, Lihong Jing, Ruirui Qiao, Mingyuan Gao*
    Chem. Comm., 2011, 47(33), 9293-9311. (Feature article)
  21. Quantum Dot-Antisense Oligonucleotide Conjugates for Multifunctional Gene Transfection, mRNA Regulation, and Tracking of Biological Processes
    Yilin Li, Xin Duan, Lihong Jing, Chunhui Yang, Ruirui Qiao, Mingyuan Gao*
    Biomaterials, 2011, 32, 1923-1931.
  22. Lateral Flow Immunochromatographic Assay for Sensitive Pesticide Detection by Using Fe3O4 Nanoparticle Aggregates as Color Reagents
    Chunyan Liu, Qiaojuan Jia, Chunhui Yang, Ruirui Qiao, Lihong Jing, Libing Wang*, Chuanlai Xu, and Mingyuan Gao*
    Anal. Chem., 2011, 83(17), 6778-6784.
  23. Highly Fluorescent CdTe@SiO2 Particles Prepared via Reverse Microemulsion Method
    Lihong Jing, Chunhui Yang, Ruirui Qiao, Mu Niu, Meihong Du, Dayang Wang, and Mingyuan Gao*
    Chem. Mater., 2010, 22(2), 420-427.
  24. Investigations on the Interactions between Plasma Proteins and Magnetic Iron Oxide Nanoparticles with Different Surface Modifications
    Shujie Liu, Yuchun Han, Ruirui Qiao, Jianfeng Zeng, Qiaojuan Jia, Yilin Wang* and Mingyuan Gao*
    J. Phys. Chem. C, 2010, 114, 21270-21276.
  25. One-pot Reaction Synthesis of PVP-coated Ni0.6Fe2.4O2 Nanocrystals
    Xianyong Lu, Mu Niu, Chunhui Yang, Luoxin Yi, Ruirui Qiao, Meihong Du and Mingyuan Gao*
    Chinese Sci. Bull., 2010, 55, 3472-3478.
  26. Monodispersed Magnetic Polystyrene Beads with Excellent Colloidal Stability and Strong Magnetic Response
    Mu Niu, Meihong Du, Zhenyu Gao, Chunhui Yang, Xianyong Lu, Ruirui Qiao and Mingyuan Gao*
    Macromol. Rapid Comm., 2010, 31, 1805-1810.
  27. A Novel Type of Dual-modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in vivo Application
    Shujie Liu1, Bing Jia1, Ruirui Qiao1, Zhi Yang, Zilin Yu, Zhaofei Liu, Kan Liu, Han Ouyang, Fan Wang*, and Mingyuan Gao*
    Mol. Pharmaceut., 2009, 6(4), 1074-1082.
  28. Superparamagnetic iron oxide nanoparticles: From preparations to in vivo MRI applications
    Ruirui Qiao, Chunhui Yang and Mingyuan Gao*
    J. Mater. Chem., 2009, 19, 6274-6293. (Feature article)
  29. Polyaniline/Fe3O4 nanoparticle Composite: Synthesis and Reaction Mechanism
    Chunhui Yang, Jingjie Du, Qian Peng, Ruirui Qiao, Wei Chen, Chuanlai Xu*, Zhigang Shuai, and Mingyuan Gao*
    J. Phys. Chem. B, 2009, 113, 5052-5058.
  30. Ultrasensitive immunoassay of 7-aminoclonazepam in human urine based on CdTe nanoparticle bioconjugations by fabricated microfluidic chip
    Wei Chen, Chifang Peng, Zhengyue Jin, Ruirui Qiao, Wuyang Wang, Shuifang Zhu, Libing Wang, Qinhui Ji, and Chuanlai Xu*
    Biosens. Bioelectron., 2009, 24(7), 2051-2056.
  31. Rapid and sensitive detection of microcystin by immunosensor based on nuclear magnetic resonance
    Wei Ma, Wei Chen, Ruirui Qiao, Chunyan Liu, Chunhui Yang, Zhuokun Li, Dinghua Xu, Chifang Peng, Zhengyu Jin, Chuanlai Xu*, Shuifang Zhu*, and Libing Wang
    Biosens. Bioelectron., 2009, 25(1), 240-243.
  32. Automated and ultrasensitive detection of methyl-3-quinoxaline-2-carboxylic acid by using gold nanoparticles probes SIA-rt-PCR
    Wei Chen, Yuan Jiang, Baoqing Ji, Changqin Zhu, Liqiang Liu, Chifang Peng, M. Kim Jin, Ruirui Qiao, Zhengyu Jin, Libing Wang, Shuifang Zhu, and Chuanlai Xu*
    Biosens. Bioelectron., 2009, 24(9), 2858-2863.
  33. Effects of quantum dots in polymerase chain reaction
    Libing Wang, Yingyue Zhu, Yuan Jiang, Ruirui Qiao, Shuifang Zhu, Wei Chen, and Chuanlai Xu*
    J. Phys. Chem. B, 2009, 113(21), 7637-7641.
  34. Super-dispersible PVP-coated Fe3O4 Nanocrystals Prepared by a “One-pot” Reaction
    Xianyong Lu, Mu Niu, Ruirui Qiao, and Mingyuan Gao*
    J. Phys. Chem. B, 2008, 112, 14390-14394.
  35. Variable-temperature NMR study of piperidin amides on the isomerization of amide bond
    Ruirui Qiao, Jing Sun, Chunhui Yang, Qiang Xiao, Yuxin Cui*
    Chinese J. Magn. Reson., 2008, 25, 307-308.
  
         申请专利  
   
  1. 表面修饰的荧光量子点/二氧化硅复合微球，其制备方法和应用
    高明远，荆莉红，乔瑞瑞
    中国发明专利申请（201110104542.X）
    申请日期：2011年4月26日
    授权日期：2014年10月29日
  2. 具有生物相容性的放射性核素掺杂的磁性纳米晶体及其制备方法
    高明远，牛牧，曾剑峰，乔瑞瑞
    中国发明专利申请（201010524510.0）
    申请日期：2010年10月29日
  
 
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