2023年12月02日，应苏州大学放射医学与防护学院、放射医学与辐射防护国家重点实验室分子影像与核医学研究中心的邀请，中国科学院长春应用化学研究所林君教授来访并进行了题为“Application of Functional Nanomaterials in Tumor Therapy”的学术报告。
       Abstract: Cancer is one of the most serious diseases that threaten the human health. It is very urgent to develop advanced technology for cancer diagnosis and therapy. The traditional cancer therapy methods include operation, chemotherapy and radiotherapy etc, which suffer from long treatment period, drug resistance, big side effect. The newly developed minimally invasive treatment processes such as photothermal (PTT)/photodynamic (PDT)/sonodynamic (SDT) therapy and immunoththerapy etc show great promise for cancer therapy, with advantages of good time-space selection, safe, low toxicity and minor side effects. In this lecture, nanomaterials based photothermal and photodynamic therapy, sonodynamic therapy and immunotherapy will discussed. For NIR (laser)-triggered PTT and PDT, we will present metal/semiconductor heterojunction structure to increase photothermal conversion efficacy, Pd/Cu single-atom nano-enzyme to realize mild temperature PTT and double photosensitisers to improve ROS yield and increase the therapy efficacy in PDT. For sonodynamic therapy (SDT), we will discuss the design and optimization strategy of sonosensitizers, including defect engineering strategy and heterojunctions route. For immunotherapy, we will present how nanomaterials function in potentiating immune response, including immunogenic cell death (ICD), construction of tumor nanovaccines and pyroptosis adjuvants. Finally, the future challenges for the application of nanomaterials in tumor therapy will be forecasted.
       Biography: Dr. Jun Lin, professor, and the group leader of luminescent and biomedical materials in Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. His research mainly focuses on luminescent materials for various applications, including photoluminescence and spectral properties of rare earth ions and peroskite QDs for applications in displays and lightening (especially for white LED), as well as multifunctional materials as theranostic agents for biomedical applications. He won Grade -1 Award for Science and Technology Progress of Jilin Province three times, and was selected in highly cited researchers in materials science and cross-field in 2014-2023. So far he has published more than 900 peer-reviewed journal articles with total citations over 70000 and H index of 140; He also gave more than 100 invited lectures in various kinds of conferences.